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Nc got7 x you 3p

By | 11.10.2020

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nc got7 x you 3p

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nc got7 x you 3p

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nc got7 x you 3p

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Got7 Album Present You&me Edition 3ver Set CD Photobook 3p Photocard Lyrics

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VMinKook (3-WAY) Moans - With YOU (18+)

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GOT7 - Spinning Top Album - Official (Random Version)

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nc got7 x you 3p

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Learn more - opens in a new window or tab. Item location:.Metrics details. Diabetic nephropathy DN is a severe complication of diabetes with type 1 and 2. In this study, we aimed to further explore the effect and underlying mechanism of plasmacytoma variant translocation 1 PVT1 in DN pathogenesis. Western blot analysis was performed to determine protein expression. Cell proliferation was detected using the 3- 4,5-dimethylthiazolyl 3-carboxymethoxyphenyl 4-sulfophenyl -2 H -tetr-azolium MTS assay.

Diabetic nephropathy DN is a severe complication of type 1 and 2 diabetes all over the world [ 12 ]. DN is histologically characterized by mesangial expansion, tubulointerstitial fibrosis and glomerulosclerosis, which are induced by the hyper-proliferation of mesangial cells MCs and the accumulation of extracellular matrix ECM proteins [ 34 ]. Although DN pathogenesis is complicated and ambiguous, hyperglycemia has been identified to contribute to the development and progression of this disease [ 2 ].

Despite significant advances in DN management, effective strategies against DN remain limited. Therefore, it is very imperative to develop new therapeutic targets for DN treatment. Emerging researches have suggested that lncRNAs are implicated in the pathogenesis and development of DN [ 789 ].

Plasmacytoma variant translocation 1 PVT1a 1. It was reported that PVT1 was up-regulated in human podocytes and mouse podocyte clone 5 podocytes after high glucose HG exposure and PVT1 knockdown attenuated HG-induced damage and apoptosis in podocytes [ 11 ].

In the current research, we aimed was to further explore the effect and underlying mechanism of PVT1 on HG-induced MCs proliferation and fibrosis. Wilms tumor protein 1 WT1 is a zinc finger-like transcription factor, which is pivotal for renal development and closely associated with tumorigenesis in the kidney [ 13 ]. WT1 has been identified to be up-regulated in diabetic patients with proteinuria, and patients with WT1-positive urinary exosomes have reduced renal function [ 14 ].

Emerging evidence has shown that urinary exosomal WT1 functions as a podocyte-specific marker for DN diagnosis and prognosis [ 1516 ]. A control sample set was obtained by the recruitment of 30 healthy volunteers, who have not suffered from DN, diabetes, inflammatory disease, or autoimmune diseases. Each participant signed written informed consent before sample collection. For miRb-3p alteration, the synthetic miRb-3p mimic or its inhibitor anti-miRb-3p was introduced into MCs, with a corresponding scrambled sequence miR-NC mimic or anti-miR-NC as the negative control.Sign in with Twitter.

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